ZFIN Image: Leung et al., 2008, Fig. 5

Image

Figure Caption

Fig. 5 L–R asymmetry of visceral organs in zebrafish embryos. (A) foxa3 expression marks the gut primordium at 36 hpf showing the liver bud (left) and pancreatic bud (right) in control embryo. (B) Graphical summary of normal visceral asymmetry in control (97.8 ± 1.3%), gpr161 knockdown (32.4 ± 4.1%) and RNA rescued (52.2 ± 3.4%) embryos. t-test (p < 0.01) results were from 6 injection experiments. n was number of total embryos. Error bars were ± SEM. (C) foxa3 expression of liver and pancreatic buds in normal L–R asymmetric position in control, symmetric or heterotaxia in gpr161 knockdown and normal L–R asymmetry in RNA rescued embryos. All scale bars were 100 μm.

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Acknowledgments

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Reprinted from Developmental Biology, 323(1), Leung, T., Humbert, J.E., Stauffer, A.M., Giger, K.E., Chen, H., Tsai, H.J., Wang, C., Mirshahi, T., and Robishaw, J.D., The orphan G protein-coupled receptor 161 is required for left-right patterning, 31-40, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.