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Fig. S6
puma depletion abrogates IR-induced apoptosis in wild-type zebrafish embryos
Lateral views of 25.5-hpf wild-type zebrafish embryos that were injected at the 1-cell stage with the indicated MOs, irradiated (0- or 12.5-Gy) at 18 hpf, and immunostained with an anti-active-caspase-3 antibody. The p53 MO-injected embryo serves as an internal control. Note that puma MO, but not puma 5bpmmMO, produces a complete phenocopy of p53 MO.
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Reprinted from Cell, 133(5), Sidi, S., Sanda, T., Kennedy, R.D., Hagen, A.T., Jette, C.A., Hoffmans, R., Pascual, J., Imamura, S., Kishi, S., Amatruda, J.F., Kanki, J.P., Green, D.R., D'Andrea, A.A., and Look, A.T., Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3, 864-877, Copyright (2008) with permission from Elsevier. Full text @ Cell