ZFIN Image: Reichenbach et al., 2008, Fig. 2

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Figure Caption

Fig. 2 Comparison of the expression of hand2 to endodermal marker foxA3 and ENS precursors marker phox2b and the reduction of ENS neurons in hand2 morphants. (A–C) Ventral views of the intestine of 60 hpf wholemount in situ hybridized embryos that have been in situ hybridized with riboprobes for foxA3 (A), hand2 (B) and phox2b (C). (D, E) Lateral views of the intestine of 96 hpf wild type (D) and hand2 morphant (E) embryos that have been stained with an anti-Hu antibody showing that there is a reduction in the overall neuron number in hand2 morphants as compared to wild type. (A–C) Yolk has been removed from the embryos. Anterior is to the left.

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Acknowledgments

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Reprinted from Developmental Biology, 318(1), Reichenbach, B., Delalande, J.M., Kolmogorova, E., Prier, A., Nguyen, T., Smith, C.M., Holzschuh, J., and Shepherd, I.T., Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish, 52-64, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.