ZFIN Image: Cunliffe et al., 2006, Fig. 1

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Figure Caption

Fig. 1 Histone deacetylase 1 is required for specification of oligodendrocytes in the zebrafish hindbrain and for expression of sox10 in neural progenitor cells of the ventral hindbrain. (A–D) dorsal views of hindbrains of wild-type (A,C) and hdac1 mutant (B,D) embryos, anterior is uppermost. (E,F) Transverse sections through hindbrain of (E) wild-type and (F) hdac1 mutant embryos at the level of rhombomere 5. A symmetrically distributed population of dispersed cells expressing the oligodendrocyte differentiation marker plp1b is present in the hindbrain of wild-type sibling embryos (A) but completely absent in hdac1 mutants (B), at 4.5 days post-fertilization (dpf). Likewise, sox10-positive neural progenitors are readily visible throughout the ventral medial part of the wild-type hindbrain (C,E) but absent in the hindbrain of hdac1 mutant embryos (D,F), at 50 hpf.

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Acknowledgments

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Reprinted from Mechanisms of Development, 123(1), Cunliffe, V.T., and Casaccia-Bonnefil, P., Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS, 24-30, Copyright (2006) with permission from Elsevier. Full text @ Mech. Dev.