Gene
plp1b
- ID
- ZDB-GENE-030710-6
- Name
- proteolipid protein 1b
- Symbol
- plp1b Nomenclature History
- Previous Names
-
- dm20 (1)
- DMalpha2a
- DMalpha2b
- DMalpha2c
- fv76c02
- wu:fv76c02
- zgc:91786
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of myelin sheath. Predicted to be involved in axon development and central nervous system myelination. Predicted to be located in membrane. Predicted to be active in myelin sheath and plasma membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu446 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 2 | Alliance | Spastic paraplegia 2, X-linked | 312920 |
| Pelizaeus-Merzbacher disease | Alliance | Pelizaeus-Merzbacher disease | 312080 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001614 | Myelin proteolipid protein PLP |
Domain Details Per Protein
| Protein | Length | Myelin proteolipid protein PLP |
|---|---|---|
|
UniProtKB:A0A8M2BCB3
|
280 | |
|
UniProtKB:Q8UUT2
|
257 | |
|
UniProtKB:Q8UUT5
|
245 | |
|
UniProtKB:Q8UUT3
|
279 |
Interactions and Pathways
No data available
Plasmids
No data available