Gene
smad1
- ID
- ZDB-GENE-991119-8
- Name
- SMAD family member 1
- Symbol
- smad1 Nomenclature History
- Previous Names
-
- madh1
- fb39h09
- sb:eu786
- SMA- and MAD-related protein 1
- wu:fb39h09 (1)
- wu:fb97e04
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables transcription cis-regulatory region binding activity. Involved in BMP signaling pathway; embryonic pattern specification; and regulation of DNA-templated transcription. Acts upstream of or within dorsal/ventral pattern formation; myeloid cell development; and negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in several structures, including artery; fin; immature eye; mesoderm; and nervous system. Orthologous to human SMAD1 (SMAD family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92101 (19 images)
- eu786 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh243 | Allele with one point mutation | Unknown | Unknown | ENU | |
| fh245 | Allele with one point mutation | Intron 2 - Exon 3 Splice Junction | Unknown | not specified | |
| la013641Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa32712 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32713 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| smad1_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
| zko668a | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zko668b | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Dwarfin | MAD homology 1, Dwarfin-type | MAD homology, MH1 | SMAD domain, Dwarfin-type | SMAD/FHA domain superfamily | SMAD-like domain superfamily | SMAD MH1 domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9I8V2
|
472 | |||||||
|
UniProtKB:Q5PQZ2
|
472 |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-194G2 | ZFIN Curated Data | |
| Encodes | EST | eu786 | Thisse et al., 2005 | |
| Encodes | EST | fb39h09 | ||
| Encodes | EST | fb97e04 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92101 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131356 (1) | 3061 nt | ||
| Genomic | GenBank:BX276105 (2) | 209486 nt | ||
| Polypeptide | UniProtKB:Q5PQZ2 (1) | 472 aa |
- Niu, M., Whang, H., Wu, Z., ShouwenJiang, ., Chen, L. (2024) The deletion of Asb15b gene can lead to a significant decrease in zebrafish intermuscular bone. Gene. 923:148561
- Cadete, F., Francisco, M., Freitas, R. (2023) Bmp-signaling and the finfold size in zebrafish: implications for the fin-to-limb transition. Evolution; international journal of organic evolution. 77(5):1262-1271
- Owen, N., Toms, M., Tian, Y., Toualbi, L., Richardson, R., Young, R., Tracey-White, D., Dhami, P., Beck, S., Moosajee, M. (2023) Loss of the crumbs cell polarity complex disrupts epigenetic transcriptional control and cell cycle progression in the developing retina. The Journal of pathology. 259(4):441-454
- Wu, Y., Sun, A., Nie, C., Gao, Z.X., Wan, S.M. (2022) Functional differentiation of bmp2a and bmp2b genes in zebrafish. Gene expression patterns : GEP. 46:119288
- Guglielmi, L., Heliot, C., Kumar, S., Alexandrov, Y., Gori, I., Papaleonidopoulou, F., Barrington, C., East, P., Economou, A.D., French, P.M.W., McGinty, J., Hill, C.S. (2021) Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways. Nature communications. 12:6374
- Li, X., Ji, G., Zhou, J., Du, J., Li, X., Shi, W., Hu, Y., Zhou, W., Hao, A. (2021) Pcgf1 Regulates Early Neural Tube Development Through Histone Methylation in Zebrafish. Frontiers in cell and developmental biology. 8:581636
- McDonald, G.L.K., Wang, M., Hammond, C.L., Bergen, D.J.M. (2021) Pharmacological Manipulation of Early Zebrafish Skeletal Development Shows an Important Role for Smad9 in Control of Skeletal Progenitor Populations. Biomolecules. 11(2):
- Peng, W., Zhang, W., Wu, Q., Cai, S., Jia, T., Sun, J., Lin, Z., Alitongbieke, G., Chen, Y., Su, Y., Lin, J., Cai, L., Sun, Y., Pan, Y., Xue, Y. (2021) Agaricus bisporus-Derived Glucosamine Hydrochloride Facilitates Skeletal Injury Repair through Bmp Signaling in Zebrafish Osteoporosis Model. Journal of natural products. 84(4):1294-1305
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Wang, W., Hu, Y.F., Pang, M., Chang, N., Yu, C., Li, Q., Xiong, J.W., Peng, Y., Zhang, R. (2021) BMP and Notch Signaling Pathways differentially regulate Cardiomyocyte Proliferation during Ventricle Regeneration. International journal of biological sciences. 17:2157-2166
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