Gene
smad5
- ID
- ZDB-GENE-990603-9
- Name
- SMAD family member 5
- Symbol
- smad5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables transcription cis-regulatory region binding activity. Involved in BMP signaling pathway and embryonic pattern specification. Acts upstream of or within several processes, including determination of ventral identity; embryonic morphogenesis; and vasculature development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in eye; margin; and posterior lateral line primordium. Orthologous to human SMAD5 (SMAD family member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 49 figures from 28 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b1100 | Allele with one point mutation | Unknown | Missense | not specified | |
| dfr3 | Allele with one point mutation | Unknown | Missense | ENU | |
| dtc24 | Allele with one point mutation | Unknown | Missense | ENU | |
| dti216c | Allele with one point mutation | Unknown | Missense | ENU | |
| dty40 | Allele with one point mutation | Unknown | Missense | ENU | |
| fr4 | Allele with one point mutation | Unknown | Missense | ENU | |
| fr5 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| la027522Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| m169 | Allele with one point mutation | Unknown | Cryptic Acceptor Splice Site, Frameshift, Premature Stop | ENU | |
| sa14393 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Dwarfin | MAD homology 1, Dwarfin-type | MAD homology, MH1 | SMAD domain, Dwarfin-type | SMAD/FHA domain superfamily | SMAD-like domain superfamily | SMAD MH1 domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9W7E7
|
464 | |||||||
|
UniProtKB:A5PMC0
|
464 |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-110E4 | ZFIN Curated Data | |
| Contains | SNP | rs3728635 | ZFIN Curated Data | |
| Contains | SNP | rs3728636 | ZFIN Curated Data | |
| Contains | SNP | rs3728637 | ZFIN Curated Data | |
| Contains | SNP | rs3728638 | ZFIN Curated Data | |
| Contains | SNP | rs3728639 | ZFIN Curated Data | |
| Contains | SNP | rs3728640 | ZFIN Curated Data | |
| Contains | SNP | rs3728641 | ZFIN Curated Data | |
| Encodes | EST | eu319 | Thisse et al., 2005 | |
| Encodes | EST | fb67b04 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131368 (1) | 2562 nt | ||
| Genomic | GenBank:BX323077 (1) | 195732 nt | ||
| Polypeptide | UniProtKB:A5PMC0 (1) | 464 aa |
- Angueyra, J.M., Kunze, V.P., Patak, L.K., Kim, H., Kindt, K., Li, W. (2023) Transcription factors underlying photoreceptor diversity. eLIFE. 12:
- Guglielmi, L., Heliot, C., Kumar, S., Alexandrov, Y., Gori, I., Papaleonidopoulou, F., Barrington, C., East, P., Economou, A.D., French, P.M.W., McGinty, J., Hill, C.S. (2021) Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways. Nature communications. 12:6374
- Li, X., Ji, G., Zhou, J., Du, J., Li, X., Shi, W., Hu, Y., Zhou, W., Hao, A. (2021) Pcgf1 Regulates Early Neural Tube Development Through Histone Methylation in Zebrafish. Frontiers in cell and developmental biology. 8:581636
- McDonald, G.L.K., Wang, M., Hammond, C.L., Bergen, D.J.M. (2021) Pharmacological Manipulation of Early Zebrafish Skeletal Development Shows an Important Role for Smad9 in Control of Skeletal Progenitor Populations. Biomolecules. 11(2):
- Peng, W., Zhang, W., Wu, Q., Cai, S., Jia, T., Sun, J., Lin, Z., Alitongbieke, G., Chen, Y., Su, Y., Lin, J., Cai, L., Sun, Y., Pan, Y., Xue, Y. (2021) Agaricus bisporus-Derived Glucosamine Hydrochloride Facilitates Skeletal Injury Repair through Bmp Signaling in Zebrafish Osteoporosis Model. Journal of natural products. 84(4):1294-1305
- Swartz, M.E., Lovely, C.B., Eberhart, J.K. (2021) Variation in phenotypes from a Bmp-Gata3 genetic pathway is modulated by Shh signaling. PLoS Genetics. 17:e1009579
- Zhang, G., Lübke, L., Chen, F., Beil, T., Takamiya, M., Diotel, N., Strähle, U., Rastegar, S. (2021) Neuron-Radial Glial Cell Communication via BMP/Id1 Signaling Is Key to Long-Term Maintenance of the Regenerative Capacity of the Adult Zebrafish Telencephalon. Cells. 10(10):
- Soh, G.H., Pomreinke, A.P., Müller, P. (2020) Integration of Nodal and BMP Signaling by Mutual Signaling Effector Antagonism. Cell Reports. 31:107487
- Tu, J., Liu, X., Jia, H., Reilly, J., Yu, S., Cai, C., Liu, F., Lv, Y., Huang, Y., Lu, Z., Han, S., Jiang, T., Shu, X., Wu, X., Tang, Z., Lu, Q., Liu, M. (2020) The chromatin remodeler Brg1 is required for formation and maintenance of hematopoietic stem cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(9):11997-12008
- Zhang, G., Ferg, M., Lübke, L., Takamiya, M., Beil, T., Gourain, V., Diotel, N., Strähle, U., Rastegar, S. (2020) Bone morphogenetic protein signaling regulates Id1-mediated neural stem cell quiescence in the adult zebrafish brain via a phylogenetically conserved enhancer module. Stem cells (Dayton, Ohio). 38(7):875-889
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