Gene
dnmt1
- ID
- ZDB-GENE-990714-15
- Name
- DNA (cytosine-5-)-methyltransferase 1
- Symbol
- dnmt1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates and molecular function inhibitor activity. Involved in DNA methylation and negative regulation of gene expression. Acts upstream of or within several processes, including camera-type eye development; digestive system development; and hemopoiesis. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and pectoral fin. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; hereditary sensory neuropathy type 1E; and lung non-small cell carcinoma. Orthologous to human DNMT1 (DNA methyltransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb983 (12 images)
- cb1075 (16 images)
- IMAGE:7140056 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 40 figures from 15 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| pd1093 | Allele with one point mutation | Unknown | Unknown | ENU | |
| rj794 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| s872 | Allele with one MNV | Unknown | Unknown | ENU | |
| s904 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa16282 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20150 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40171 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40172 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40173 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40174 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 10 of 11
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant cerebellar ataxia, deafness and narcolepsy | Alliance | Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant | 604121 |
| hereditary sensory neuropathy type 1E | Alliance | Neuropathy, hereditary sensory, type IE | 614116 |
1 - 2 of 2
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018117 | DNA methylase, C-5 cytosine-specific, active site |
| Conserved_site | IPR031303 | DNA methylase, C-5 cytosine-specific, conserved site |
| Domain | IPR001025 | Bromo adjacent homology (BAH) domain |
| Domain | IPR002857 | Zinc finger, CXXC-type |
| Domain | IPR010506 | DMAP1-binding domain |
1 - 5 of 11 Show all
Domain Details Per Protein
| Protein | Length | Bromo adjacent homology (BAH) domain | Bromo adjacent homology (BAH) domain superfamily | C-5 cytosine methyltransferase | DMAP1-binding domain | DNA Cytosine-5 Methyltransferase | DNA (cytosine-5)-methyltransferase 1-like | DNA (cytosine-5)-methyltransferase 1, replication foci domain | DNA methylase, C-5 cytosine-specific, active site | DNA methylase, C-5 cytosine-specific, conserved site | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Zinc finger, CXXC-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YUX4
|
1505 | |||||||||||
|
UniProtKB:F1RCN0
|
1500 |
1 - 2 of 2
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-dnmt1 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
9 |
1 - 1 of 1
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-160J1 | ZFIN Curated Data | |
| Encodes | EST | cb983 | Thisse et al., 2001 | |
| Encodes | EST | cb1075 | Thisse et al., 2001 | |
| Encodes | EST | fb05h01 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7140056 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:66111 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195320 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195321 | ZFIN Curated Data |
1 - 8 of 8
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131189 (1) | 4935 nt | ||
| Genomic | GenBank:CU571160 (2) | 81776 nt | ||
| Polypeptide | UniProtKB:A0A8M6YUX4 (1) | 1505 aa |
- Cai, H., Zheng, N., Tang, C., Zhang, Y., Zuo, Z., He, C. (2024) Tributyltin causes generational neurodevelopmental toxicity and the protective effect of folic acid in zebrafish. Journal of environmental sciences (China). 137:615625615-625
- Lawir, D.F., Soza-Ried, C., Iwanami, N., Siamishi, I., Bylund, G.O., O Meara, C., Sikora, K., Kanzler, B., Johansson, E., Schorpp, M., Cauchy, P., Boehm, T. (2024) Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Communications biology. 7:3131
- Madakashira, B.P., Magnani, E., Ranjan, S., Sadler, K.C. (2024) DNA hypomethylation activates Cdk4/6 and Atr to induce DNA replication and cell cycle arrest to constrain liver outgrowth in zebrafish. Nucleic acids research. 52(6):3069-3087
- Salazar, M., Joly, S., Anglada-Escudé, G., Ribas, L. (2024) Epigenetic and physiological alterations in zebrafish subjected to hypergravity. PLoS One. 19:e0300310e0300310
- Wang, A., Wan, X., Zhu, F., Liu, H., Song, X., Huang, Y., Zhu, L., Ao, Y., Zeng, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Li, H., Zhuang, P., Jiao, J., Zhang, Y. (2024) Habitual Daily Intake of Fried Foods Raises Transgenerational Inheritance Risk of Heart Failure Through NOTCH1-Triggered Apoptosis. Research (Washington, D.C.). 7:04010401
- Zhao, S., Mo, G., Wang, Q., Xu, J., Yu, S., Huang, Z., Liu, W., Zhang, W. (2024) Role of RB1 in neurodegenerative diseases: inhibition of post-mitotic neuronal apoptosis via Kmt5b. Cell death discovery. 10:182182
- Ma, J., Yang, Z., Huang, Z., Li, L., Huang, J., Chen, J., Ni, R., Luo, L., He, J. (2023) Rngtt governs biliary-derived liver regeneration initiation by transcriptional regulation of mTORC1 and Dnmt1 in zebrafish. Hepatology (Baltimore, Md.). 78(1):167-178
- Chen, C., He, M., Li, X., Yu, L., Liu, Y., Yang, Y., Li, L., Jia, J., Li, B. (2022) H2O2/DEM-Promoted Maft Promoter Demethylation Drives Nrf2/ARE Activation in Zebrafish. Life (Basel, Switzerland). 12(9)
- Li, Y., Tang, C., Liu, F., Zhu, C., Liu, F., Zhu, P., Wang, L. (2022) DNA methylation safeguards the generation of hematopoietic stem and progenitor cells by repression of Notch signaling. Development (Cambridge, England). 149(10):
- Tang, D., Zheng, S., Zheng, Z., Liu, C., Zhang, J., Yan, R., Wu, C., Zuo, N., Wu, L., Xu, H., Liu, S., He, Y. (2022) Dnmt1 is required for the development of auditory organs via cell cycle arrest and Fgf signalling. Cell Proliferation. 55(5):e13225
1 - 10 of 110
Show