Gene

sema4c

ID

ZDB-GENE-080303-16

Name

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C

Symbol

sema4c Nomenclature History

Previous Names

sc:d411 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have chemorepellent activity and semaphorin receptor binding activity. Predicted to be involved in several processes, including negative regulation of axon extension involved in axon guidance; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to localize to extracellular space and integral component of plasma membrane. Is expressed in several structures, including axial mesoderm; brain; lens placode; olfactory epithelium; and solid lens vesicle. Orthologous to human SEMA4C (semaphorin 4C).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cssl:d411 (17 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Sheng et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sema4c Human Ortholog

No data available

Associated With sema4c Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001627	Sema domain
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR016201	PSI domain
Family	IPR027231	Semaphorin
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily
Homologous_superfamily	IPR036352	Sema domain superfamily
Repeat	IPR002165	Plexin repeat