Gene
grk1a
- ID
- ZDB-GENE-050823-1
- Name
- G protein-coupled receptor kinase 1 a
- Symbol
- grk1a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Exhibits rhodopsin kinase activity. Predicted to be involved in several processes, including protein phosphorylation; regulation of rhodopsin mediated signaling pathway; and visual perception. Human ortholog(s) of this gene implicated in Oguchi disease-2 and night blindness. Is expressed in epiphysis; eye; retinal photoreceptor layer; and retinal rod cell. Orthologous to human GRK1 (G protein-coupled receptor kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Oguchi disease-2 | Alliance | Oguchi disease-2 | 613411 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR000961 | AGC-kinase, C-terminal |
Domain | IPR016137 | RGS domain |
Domain | IPR037716 | Rhodopsin kinase, catalytic domain |
Family | IPR000239 | GPCR kinase |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Homologous_superfamily | IPR036305 | RGS domain superfamily |
Homologous_superfamily | IPR044926 | RGS, subdomain 2 |
Domain Details Per Protein
Protein | Length | AGC-kinase, C-terminal | GPCR kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | RGS domain | RGS domain superfamily | RGS, subdomain 2 | Rhodopsin kinase, catalytic domain | Serine/threonine-protein kinase, active site |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q1XHM0
|
563 |
Interactions and Pathways
No data available
Plasmids
No data available