Gene
gla
- ID
- ZDB-GENE-041010-207
- Name
- galactosidase, alpha
- Symbol
- gla Nomenclature History
- Previous Names
-
- zgc:101584
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have alpha-galactosidase activity. Predicted to be involved in glycoside catabolic process; glycosylceramide catabolic process; and oligosaccharide metabolic process. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in Fabry disease. Orthologous to human GLA (galactosidase alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101584 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Fabry disease | Alliance | Fabry disease | 301500 |
Fabry disease | Alliance | Fabry disease, cardiac variant | 301500 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
Fabry disease | glahuh1/huh1 (AB/TU) | standard conditions | Elsaid et al., 2023 |
Fabry disease | glahuh1/huh1 | standard conditions | Elsaid et al., 2022 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR000111 | Glycoside hydrolase family 27/36, conserved site |
Domain | IPR035373 | Alpha galactosidase A, C-terminal beta-sandwich domain |
Family | IPR002241 | Glycoside hydrolase, family 27 |
Homologous_superfamily | IPR013780 | Glycosyl hydrolase, all-beta |
Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
Homologous_superfamily | IPR017853 | Glycoside hydrolase superfamily |
Domain Details Per Protein
Protein | Length | Aldolase-type TIM barrel | Alpha galactosidase A, C-terminal beta-sandwich domain | Glycoside hydrolase, family 27 | Glycoside hydrolase family 27/36, conserved site | Glycoside hydrolase superfamily | Glycosyl hydrolase, all-beta |
---|---|---|---|---|---|---|---|
UniProtKB:F1Q5G5
|
409 |
Interactions and Pathways
No data available
Plasmids
No data available