Gene
mep1a.1
- ID
- ZDB-GENE-041001-209
- Name
- meprin A, alpha (PABA peptide hydrolase), tandem duplicate 1
- Symbol
- mep1a.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to membrane. Is expressed in several structures, including brush border epithelial cell; digestive system; epidermis; gill; and heart. Orthologous to human MEP1A (meprin A subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Schütte et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000998 | MAM domain |
| Domain | IPR001506 | Peptidase M12A |
| Domain | IPR002083 | MATH/TRAF domain |
| Domain | IPR006026 | Peptidase, metallopeptidase |
| Homologous_superfamily | IPR008974 | TRAF-like |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Length | Concanavalin A-like lectin/glucanase domain superfamily | MAM domain | MATH/TRAF domain | Metallopeptidase, catalytic domain superfamily | Peptidase M12A | Peptidase, metallopeptidase | TRAF-like |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5RHM1
|
598 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mep1a.1-201
(1)
|
Ensembl | 1,983 nt | ||
| ncRNA |
mep1a.1-002
(1)
|
Ensembl | 664 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-mep1a.1 | polyclonal |
|
1 |
Plasmids
No data available
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- This gene and mep1a.2 (ZDB-GENE-041001-208) are located next to each other in the genome and appear to be the result of a tandem duplication. The tandem duplicates appear to be the orthologs of human MEP1A and mouse Mep1a based on amino acid identity and conserved location.