Gene

ptk2aa

ID

ZDB-GENE-031114-5

Name

protein tyrosine kinase 2aa

Symbol

ptk2aa Nomenclature History

Previous Names

ptk2.2
fak1b (1)
fakb (1)
si:ch1073-355e8.1

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have ATP binding activity and protein tyrosine kinase activity. Involved in protein localization. Predicted to localize to cytoskeleton; focal adhesion; and integral component of membrane. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Is expressed in head; midbrain; midbrain hindbrain boundary; and paraxial mesoderm. Orthologous to human PTK2 (protein tyrosine kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ptk2aa Human Ortholog

No data available

Associated With ptk2aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000299	FERM domain
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR005189	Focal adhesion kinase, targeting (FAT) domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR041390	Focal adhesion kinase, N-terminal
Domain	IPR041784	FAK1/PYK2, FERM domain C-lobe
Domain	IPR049385	FAK1-like, FERM domain C-lobe
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain
Homologous_superfamily	IPR036137	Focal adhesion kinase, targeting (FAT) domain superfamily

Domain Details Per Protein

Protein	Length	Band 4.1 domain	FAK1-like, FERM domain C-lobe	FAK1/PYK2, FERM domain C-lobe	FERM/acyl-CoA-binding protein superfamily	FERM central domain	FERM domain	FERM superfamily, second domain	Focal adhesion kinase, N-terminal	Focal adhesion kinase, targeting (FAT) domain	Focal adhesion kinase, targeting (FAT) domain superfamily	PH-like domain superfamily	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain	Ubiquitin-like domain superfamily
UniProtKB:Q7T2V4 InterPro	1045

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ptk2aa-201 (1) Ensembl	Ensembl	2,931 nt	Select Tool ZFIN BLAST
mRNA	ptk2aa-202 (1) Ensembl	Ensembl	295 nt	Select Tool ZFIN BLAST
mRNA	ptk2aa-203 (1) Ensembl	Ensembl	1,150 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-ptk2	polyclonal	ptk2aa ptk2ab	IgG	Rabbit	IHC	Life Technologies (Invitrogen)	10
Ab3-ptk2	monoclonal	ptk2aa	IgG1 , k	Mouse	WB	Santa Cruz Biotechnology, Inc.	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations