Gene
ptk2ab
- ID
- ZDB-GENE-020114-1
- Name
- protein tyrosine kinase 2ab
- Symbol
- ptk2ab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity and protein tyrosine kinase activity. Involved in lens fiber cell morphogenesis and protein localization. Predicted to localize to dendritic spine and focal adhesion. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Is expressed in eye; notochord; segmental plate; somite; and vertical myoseptum. Orthologous to human PTK2 (protein tyrosine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000299 | FERM domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR005189 | Focal adhesion kinase, targeting (FAT) domain |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR041390 | Focal adhesion kinase, N-terminal |
| Domain | IPR041784 | FAK1/PYK2, FERM domain C-lobe |
| Domain | IPR049385 | FAK1-like, FERM domain C-lobe |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR014352 | FERM/acyl-CoA-binding protein superfamily |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
| Homologous_superfamily | IPR036137 | Focal adhesion kinase, targeting (FAT) domain superfamily |
Domain Details Per Protein
| Protein | Length | Band 4.1 domain | FAK1-like, FERM domain C-lobe | FAK1/PYK2, FERM domain C-lobe | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM domain | FERM superfamily, second domain | Focal adhesion kinase, N-terminal | Focal adhesion kinase, targeting (FAT) domain | Focal adhesion kinase, targeting (FAT) domain superfamily | PH-like domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PM62
|
1132 | ||||||||||||||||||
|
UniProtKB:A0A8M9PJ68
|
1139 | ||||||||||||||||||
|
UniProtKB:A0A8M2B500
|
1091 | ||||||||||||||||||
|
UniProtKB:A0A8M9PM54
|
1139 | ||||||||||||||||||
|
UniProtKB:A0A8M2B527
|
1097 | ||||||||||||||||||
|
UniProtKB:A0A2R8RR02
|
1101 | ||||||||||||||||||
|
UniProtKB:A0A8M9PJ73
|
1126 | ||||||||||||||||||
|
UniProtKB:Q98SN4
|
1050 | ||||||||||||||||||
|
UniProtKB:A0A8M9NZ24
|
1107 | ||||||||||||||||||
|
UniProtKB:A0A8M9PCW2
|
1140 | ||||||||||||||||||
|
UniProtKB:A0A8M9PCX0
|
1104 | ||||||||||||||||||
|
UniProtKB:A0A8M2B4I9
|
1088 | ||||||||||||||||||
|
UniProtKB:A0A8M9P7Q1
|
1142 | ||||||||||||||||||
|
UniProtKB:A0A8M9P7Q4
|
1136 | ||||||||||||||||||
|
UniProtKB:A0A8M2B4H7
|
1104 | ||||||||||||||||||
|
UniProtKB:A0A8M9P7Q9
|
1104 | ||||||||||||||||||
|
UniProtKB:A0A8M9NZ18
|
1136 | ||||||||||||||||||
|
UniProtKB:A0A8M9PCW5
|
1133 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptk2ab-201
(1)
|
Ensembl | 3,874 nt | ||
| mRNA |
ptk2ab-202
(1)
|
Ensembl | 3,299 nt | ||
| mRNA |
ptk2ab-203
(1)
|
Ensembl | 6,468 nt | ||
| mRNA |
ptk2ab-211
(1)
|
Ensembl | 5,753 nt | ||
| mRNA |
ptk2ab-212
(1)
|
Ensembl | 5,865 nt | ||
| mRNA |
ptk2ab-213
(1)
|
Ensembl | 6,036 nt | ||
| mRNA |
ptk2ab-214
(1)
|
Ensembl | 6,486 nt | ||
| mRNA |
ptk2ab-215
(1)
|
Ensembl | 5,664 nt | ||
| mRNA |
ptk2ab-216
(1)
|
Ensembl | 6,015 nt | ||
| ncRNA |
ptk2ab-002
(1)
|
Ensembl | 845 nt | ||
| ncRNA |
ptk2ab-003
(1)
|
Ensembl | 885 nt | ||
| ncRNA |
ptk2ab-005
(1)
|
Ensembl | 768 nt | ||
| ncRNA |
ptk2ab-006
(1)
|
Ensembl | 645 nt | ||
| ncRNA |
ptk2ab-008
(1)
|
Ensembl | 537 nt | ||
| ncRNA |
ptk2ab-009
(1)
|
Ensembl | 808 nt | ||
| ncRNA |
ptk2ab-011
(1)
|
Ensembl | 722 nt |
Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ptk2 | polyclonal | IgG | Rabbit |
|
Life Technologies (Invitrogen)
|
10 | |
| Ab1-ptk2.1 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
5 |
Plasmids
No data available