Gene
tln1
- ID
- ZDB-GENE-031002-48
- Name
- talin 1
- Symbol
- tln1 Nomenclature History
- Previous Names
-
- sb:cb854
- wu:fb05c02
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity. Acts upstream of or within several processes, including embryonic organ morphogenesis; muscle cell development; and skeletal muscle tissue development. Predicted to be located in several cellular components, including cytoplasm; cytoskeleton; and ruffle. Predicted to be active in focal adhesion and plasma membrane. Is expressed in several structures, including adaxial cell; cardiovascular system; cranium; musculature system; and nervous system. Orthologous to human TLN1 (talin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb854 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| f102k | Allele with one point mutation | Donor Splice Site of Intron 9 | Splice Site, Intron Gain of Intron 9, Premature Stop | ENU | |
| hi3093Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| sa2572 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa5825 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa6161 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10075 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11348 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15487 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21664 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21665 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Alpha-catenin/vinculin-like superfamily | Band 4.1 domain | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM conserved site | FERM domain | FERM superfamily, second domain | I/LWEQ domain | I/LWEQ domain superfamily | IRS-type PTB domain | PH-like domain superfamily | Talin-1/2, rod-segment | Talin 1-like, rod-segment domain | Talin, central | Talin, central domain superfamily | Talin, IBS2B domain | Talin, N-terminal F0 domain | Talin, R4 domain | Vinculin-binding site-containing domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PTJ3
|
2561 | |||||||||||||||||||
|
UniProtKB:A0A8M2B1K5
|
2560 | |||||||||||||||||||
|
UniProtKB:Q5U7N6
|
2538 | |||||||||||||||||||
|
UniProtKB:A0A8M9Q646
|
2542 | |||||||||||||||||||
|
UniProtKB:A0A8M2B1Z7
|
2541 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-30O2 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-42J10 | ZFIN Curated Data | |
| Contains | STS | chunp30554 | ||
| Encodes | EST | cb854 | Thisse et al., 2001 | |
| Encodes | EST | fb05c02 | ||
| Encodes | cDNA | MGC:162832 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001009560 (1) | 7938 nt | ||
| Genomic | GenBank:BX323809 (2) | 194108 nt | ||
| Polypeptide | UniProtKB:A0A8M9PTJ3 (1) | 2561 aa |
- Chau, T.C.Y., Keyser, M.S., Da Silva, J.A., Morris, E.K., Yordanov, T.E., Duscyz, K.P., Paterson, S., Yap, A.S., Hogan, B.M., Lagendijk, A.K. (2022) Dynamically regulated focal adhesions coordinate endothelial cell remodelling in developing vasculature. Development (Cambridge, England). 149(23):
- Yamaguchi, N., Zhang, Z., Schneider, T., Wang, B., Panozzo, D., Knaut, H. (2022) Rear traction forces drive adherent tissue migration in vivo. Nature cell biology. 24:194-204
- Hu, J., Chen, L., Yin, J., Yin, H., Huang, Y., Tian, J. (2020) Hyperactivity, Memory Defects, and Craniofacial Abnormalities in Zebrafish fmr1 Mutant Larvae. Behavior Genetics. 50(3):152-160
- Olson, H.M., Nechiporuk, A.V. (2020) Lamellipodia-like protrusions and focal adhesions contribute to collective cell migration in zebrafish. Developmental Biology. 469:125-134
- Weaver, M.L., Piedade, W.P., Meshram, N.N., Famulski, J.K. (2020) Hyaloid vasculature and mmp2 activity play a role during optic fissure fusion in zebrafish. Scientific Reports. 10:10136
- Gunawan, F., Gentile, A., Fukuda, R., Tsedeke, A.T., Jiménez-Amilburu, V., Ramadass, R., Iida, A., Sehara-Fujisawa, A., Stainier, D.Y.R. (2019) Focal adhesions are essential to drive zebrafish heart valve morphogenesis. The Journal of cell biology. 218(3):1039-1054
- Hu, R., Huang, W., Liu, J., Jin, M., Wu, Y., Li, J., Wang, J., Yu, Z., Wang, H., Cao, Y. (2019) Mutagenesis of putative ciliary genes with the CRISPR/Cas9 system in zebrafish identifies genes required for retinal development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(4):5248-5256
- Ishii, K., Mukherjee, K., Okada, T., Liao, E.C. (2018) Genetic Requirement of talin1 for Proliferation of Cranial Neural Crest Cells during Palate Development.. Plastic and reconstructive surgery. Global open. 6:e1633
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- James, A., Lee, C., Williams, A.M., Angileri, K., Lathrop, K.L., Gross, J.M. (2016) The Hyaloid Vasculature Facilitates Basement Membrane Breakdown During Choroid Fissure Closure in the Zebrafish Eye. Developmental Biology. 419(2):262-272
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