Gene
tln1
- ID
- ZDB-GENE-031002-48
- Name
- talin 1
- Symbol
- tln1 Nomenclature History
- Previous Names
-
- sb:cb854
- wu:fb05c02
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have actin filament binding activity and clathrin binding activity. Involved in animal organ development and sarcomere organization. Predicted to localize to cytoskeleton; focal adhesion; and ruffle. Is expressed in several structures, including adaxial cell; cardiovascular system; cranium; musculature system; and nervous system. Orthologous to human TLN1 (talin 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb854 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR019747 | FERM conserved site |
Domain | IPR000299 | FERM domain |
Domain | IPR002404 | IRS-type PTB domain |
Domain | IPR002558 | I/LWEQ domain |
Domain | IPR015009 | Vinculin-binding site-containing domain |
Domain | IPR015224 | Talin, central |
Domain | IPR019748 | FERM central domain |
Domain | IPR019749 | Band 4.1 domain |
Domain | IPR032425 | Talin, N-terminal F0 domain |
Domain | IPR037438 | Talin-1/2, rod-segment |
Domain | IPR049108 | Talin, R4 domain |
Domain | IPR054060 | Talin 1-like, rod-segment domain |
Domain | IPR054082 | Talin, IBS2B domain |
Homologous_superfamily | IPR011993 | PH-like domain superfamily |
Homologous_superfamily | IPR014352 | FERM/acyl-CoA-binding protein superfamily |
Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
Homologous_superfamily | IPR035964 | I/LWEQ domain superfamily |
Homologous_superfamily | IPR036476 | Talin, central domain superfamily |
Homologous_superfamily | IPR036723 | Alpha-catenin/vinculin-like superfamily |
Domain Details Per Protein
Protein | Length | Alpha-catenin/vinculin-like superfamily | Band 4.1 domain | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM conserved site | FERM domain | FERM superfamily, second domain | I/LWEQ domain | I/LWEQ domain superfamily | IRS-type PTB domain | PH-like domain superfamily | Talin-1/2, rod-segment | Talin 1-like, rod-segment domain | Talin, central | Talin, central domain superfamily | Talin, IBS2B domain | Talin, N-terminal F0 domain | Talin, R4 domain | Vinculin-binding site-containing domain |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9PTJ3
|
2561 | |||||||||||||||||||
UniProtKB:A0A8M2B1K5
|
2560 | |||||||||||||||||||
UniProtKB:Q5U7N6
|
2538 | |||||||||||||||||||
UniProtKB:A0A8M9Q646
|
2542 | |||||||||||||||||||
UniProtKB:A0A8M2B1Z7
|
2541 |
Interactions and Pathways
No data available
Plasmids
No data available