Gene

tln1

ID
ZDB-GENE-031002-48
Name
talin 1
Symbol
tln1 Nomenclature History
Previous Names
  • sb:cb854
  • wu:fb05c02
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity and clathrin binding activity. Involved in animal organ development and sarcomere organization. Predicted to localize to cytoskeleton; focal adhesion; and ruffle. Is expressed in several structures, including adaxial cell; cardiovascular system; cranium; musculature system; and nervous system. Orthologous to human TLN1 (talin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
19 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tln1 Human Ortholog
No data available
Associated With tln1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019747 FERM conserved site
Domain IPR000299 FERM domain
Domain IPR002404 IRS-type PTB domain
Domain IPR002558 I/LWEQ domain
Domain IPR015009 Vinculin-binding site-containing domain
Domain IPR015224 Talin, central
Domain IPR019748 FERM central domain
Domain IPR019749 Band 4.1 domain
Domain IPR032425 Talin, N-terminal F0 domain
Domain IPR037438 Talin-1/2, rod-segment
Domain IPR049108 Talin, R4 domain
Domain IPR054060 Talin 1-like, rod-segment domain
Domain IPR054082 Talin, IBS2B domain
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR014352 FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily IPR035963 FERM superfamily, second domain
Homologous_superfamily IPR035964 I/LWEQ domain superfamily
Homologous_superfamily IPR036476 Talin, central domain superfamily
Homologous_superfamily IPR036723 Alpha-catenin/vinculin-like superfamily
Domain Details Per Protein
Protein Length Alpha-catenin/vinculin-like superfamily Band 4.1 domain FERM/acyl-CoA-binding protein superfamily FERM central domain FERM conserved site FERM domain FERM superfamily, second domain I/LWEQ domain I/LWEQ domain superfamily IRS-type PTB domain PH-like domain superfamily Talin-1/2, rod-segment Talin 1-like, rod-segment domain Talin, central Talin, central domain superfamily Talin, IBS2B domain Talin, N-terminal F0 domain Talin, R4 domain Vinculin-binding site-containing domain
UniProtKB:A0A8M9PTJ3 2561
UniProtKB:A0A8M2B1K5 2560
UniProtKB:Q5U7N6 2538
UniProtKB:A0A8M9Q646 2542
UniProtKB:A0A8M2B1Z7 2541
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tln1-201 (1) Ensembl 8,746 nt
mRNA tln1-202 (1) Ensembl 7,929 nt
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-tln1 monoclonal Mouse
Santa Cruz Biotechnology, Inc.
1
Ab1-tln1 polyclonal
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations