Gene
gpx4b
- ID
- ZDB-GENE-030410-3
- Name
- glutathione peroxidase 4b
- Symbol
- gpx4b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable peroxidase activity. Acts upstream of or within negative regulation of Wnt signaling pathway. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; blastoderm; digestive system; musculature system; and visual system. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb692 (20 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylometaphyseal dysplasia Sedaghatian type | Alliance | Spondylometaphyseal dysplasia, Sedaghatian type | 250220 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glutathione peroxidase | Glutathione peroxidase active site | Glutathione peroxidase conserved site | Thioredoxin-like superfamily |
|---|---|---|---|---|---|
|
UniProtKB:B5DDU3
|
112 | ||||
|
UniProtKB:A0A8M1N743
|
191 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-gpx4 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids
No data available