Gene
gpx4a
- ID
- ZDB-GENE-030410-2
- Name
- glutathione peroxidase 4a
- Symbol
- gpx4a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Predicted to be involved in oxidation-reduction process and response to oxidative stress. Predicted to localize to mitochondrion and nucleus. Is expressed in epidermal superficial stratum; gut; liver; and yolk syncytial layer. Orthologous to human GPX4 (glutathione peroxidase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb563 (7 images)
- cb691 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Mendieta-Serrano et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylometaphyseal dysplasia Sedaghatian type | Alliance | Spondylometaphyseal dysplasia, Sedaghatian type | 250220 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glutathione peroxidase | Glutathione peroxidase active site | Glutathione peroxidase conserved site | Thioredoxin-like superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M1N2T9
|
186 | ||||
|
UniProtKB:A0A8M1PAF3
|
194 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-gpx4 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids
No data available