Gene
ywhae1
- ID
- ZDB-GENE-030131-779
- Name
- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1
- Symbol
- ywhae1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable monooxygenase activity. Predicted to be involved in regulation of mitotic cell cycle and signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including immature eye; nervous system; otic vesicle; post-vent region; and tail bud. Orthologous to human YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55377 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la019253Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| zf387Et | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | 14-3-3 domain | 14-3-3 domain superfamily | 14-3-3 protein | 14-3-3 protein, conserved site |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QBU3
|
240 | ||||
|
UniProtKB:Q7ZW20
|
255 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ywhae1-201
(1)
|
Ensembl | 1,777 nt | ||
| mRNA |
ywhae1-202
(1)
|
Ensembl | 755 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ywhae1 | polyclonal | Rabbit |
|
Millipore
|
3 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-151P21 | ZFIN Curated Data | |
| Encodes | EST | fb48f06 | ||
| Encodes | EST | fe38c12 | ||
| Encodes | EST | fi22e10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55377 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77062 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:172188 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192298 | ZFIN Curated Data | |
| Has Artifact | EST | fc64c05 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212605 (1) | 1994 nt | ||
| Genomic | GenBank:CR524483 (2) | 210342 nt | ||
| Polypeptide | UniProtKB:Q7ZW20 (1) | 255 aa |
- Biswas, S., Chawda, M., Gudi, R., Bellare, J. (2023) Neuroprotective effects of nanogold-based Ayurveda medicine Suvarna Bhasma against rotenone-induced Parkinson's-like model. Journal of Ayurveda and integrative medicine. 15:100854100854
- Antón-Galindo, E., Dalla Vecchia, E., Orlandi, J.G., Castro, G., Gualda, E.J., Young, A.M.J., Guasch-Piqueras, M., Arenas, C., Herrera-Úbeda, C., Garcia-Fernàndez, J., Aguado, F., Loza-Alvarez, P., Cormand, B., Norton, W.H.J., Fernàndez-Castillo, N. (2022) Deficiency of the ywhaz gene, involved in neurodevelopmental disorders, alters brain activity and behaviour in zebrafish. Molecular psychiatry. 27(9):3739-3748
- Dubińska-Magiera, M., Niedbalska-Tarnowska, J., Migocka-Patrzałek, M., Posyniak, E., Daczewska, M. (2020) Characterization of Hspb8 in Zebrafish. Cells. 9(6):
- Cao, J., Tan, X. (2018) Comparative and evolutionary analysis of the 14-3-3 family genes in eleven fishes. Gene. 662:76-82
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Gebriel, M., Prabhudesai, S., Uleberg, K.E., Larssen, E., Piston, D., Bjørnstad, A.H., Møller, S.G. (2014) Zebrafish brain proteomics reveals central proteins involved in neurodegeneration. Journal of neuroscience research. 92(1):104-15
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Zhuo, H.Q., Huang, L., Huang, H.Q., and Cai, Z. (2012) Effects of chronic tramadol exposure on the zebrafish brain: A proteomic study. Journal of proteomics. 75(11):3351-3364
- Singh, S.K., Sundaram, C.S., Shanbhag, S., and Idris, M.M. (2010) Proteomic profile of zebrafish brain based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis. Zebrafish. 7(2):169-177
- Garnett, A.T., Han, T.M., Gilchrist, M.J., Smith, J.C., Eisen, M.B., Wardle, F.C., and Amacher, S.L. (2009) Identification of direct T-box target genes in the developing zebrafish mesoderm. Development (Cambridge, England). 136(5):749-760
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