PUBLICATION

Comparative and evolutionary analysis of the 14-3-3 family genes in eleven fishes

Authors
Cao, J., Tan, X.
ID
ZDB-PUB-180418-37
Date
2018
Source
Gene   662: 76-82 (Journal)
Registered Authors
Keywords
14-3-3, Evolution, Expression, Selection pressure, Synteny analysis
MeSH Terms
  • 14-3-3 Proteins/genetics*
  • 14-3-3 Proteins/metabolism
  • Amino Acid Sequence/genetics
  • Animals
  • Biological Evolution
  • Evolution, Molecular
  • Fish Proteins/genetics
  • Fishes/genetics*
  • Gene Expression Profiling/methods
  • Phylogeny
  • Sequence Analysis, DNA/methods
  • Synteny/genetics
  • Zebrafish/genetics
PubMed
29653226 Full text @ Gene
Abstract
14-3-3 proteins are a type of highly conserved acidic proteins, which are distributed over a wide variety of organisms and are involved in multiple cellular processes. While the comparative and evolutionary analysis of this gene family is unavailable in various fish species. In this study, we identified 101 putative 14-3-3 genes in 11 fish species and divided them into 5 groups via phylogenetic analysis. Synteny analysis implied conserved and dynamic evolution characteristics near the 14-3-3 gene loci in some vertebrates. We also found that some recombination events have accelerated the evolution of this gene family. Moreover, a positive selection site was also identified, and mutation of this site could reduce the 14-3-3 stability. Divergent expression profiles of the zebrafish 14-3-3 genes were further investigated under organophosphorus stress, suggesting that they may be involved in the different osmoregulation and immune response. The results will serve as a foundation for the further functional investigation into the 14-3-3 genes in fishes.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping