FIGURE

Fig. 2

ID

ZDB-FIG-240605-7

Publication

Whyte-Fagundes et al., 2024 - Testing of putative antiseizure medications in a preclinical Dravet syndrome zebrafish model

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Fig. 2

Toxicology assay for larvae following behavioral assessment. (A) Percent survival of WT and scn1lab larvae (N = 30 or 40 per condition with minimum independent 3 replicates). Percentage of larvae that did not survive are overlayed. Vorinostat at 100 µM significantly reduced scn1lab survival compared to DMSO-treated controls. (B) Radar plot quantifying touch responses of WT larvae (N = 30 or 40 per condition with minimum independent three replicates). Dotted lines segment each candidate ASM and toxicity is plotted as a percentage of larvae. Toxic ASMs are labelled. (C) Radar plot showing candidate ASM toxicity for scn1lab larvae (N = 30 or 40 per condition with minimum independent three replicates). (D) Radar plot of WT and scn1lab toxicity overlayed. 1-EBIO and Chlorzoxazone were toxic for both populations. Donepezil uniquely impacted WT larvae. One-way ANOVA was performed for statistical analysis, P < 0.01 = *, P < 0.0001 = **.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT scn1lab^s552/s552
Conditions:	chemical treatment by environment: sodium channel modulator chemical treatment by environment: Pargyline
Observed In:	optic tectum
Stage:	Day 5

Phenotype Detail

Acknowledgments

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