FIGURE

Fig 6

ID
ZDB-FIG-240511-6
Publication
Ahuja et al., 2024 - The development of brain pericytes requires expression of the transcription factor nkx3.1 in intermediate precursors
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Fig 6

nkx3.1 is essential in pericyte precursors.

Model of nkx3.1 in pericyte differentiation. nkx3.1 is expressed in cells of both mesodermal and neural crest origin as determined by lineage analysis. All embryo schematics show a dorsal view of the hindbrain. At 16 and 24 hpf, nkx3.1 and cxcl12b coexpressing precursors are located ventrolaterally. At 36 hpf, nkx3.1, cxcl12b, tbx18, and foxf2 coexpressing precursors surround the developing basilar artery (BA). By 75 hpf, pdgfrβ-expressing pericytes derived from nkx3.1 precursors have migrated to the central arteries of the brain. Key genetic markers are indicated.
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Acknowledgments
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