FIGURE

Fig. 7

ID

ZDB-FIG-240509-40

Publication

Tucker et al., 2024 - Zebrafish raptor mutation inhibits the activity of mTORC1, inducing craniofacial defects due to autophagy-induced neural crest cell death

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Fig. 7

Chemical inhibition of apoptosis partially rescues the Meckel's cartilage defect. (A) Length of Meckel's cartilage in untreated wild type, untreated mutants and 25 μM caspase-treated mutants. Each point represents one side of the lower jaw (Meckel's cartilage). The statistical analyses were conducted using one-way ANOVA followed by Tukey's honest significant difference (HSD) post-hoc test for multiple comparisons, *P<0.05, ****P<0.0001. (B-D) Ventral views of 4 dpf fish, anterior is towards the left. The top and bottom of each box correspond to the third quartile (Q3) and first quartile (Q1), respectively. Each box covers the interquartile range (IQR), where 50% of the data lies. The median is depicted by the horizontal line within each box. The upper whisker extends to the largest value within Q3 + 1.5 * IQR. The lower whisker extends to the smallest value within Q1 - 1.5 * IQR. Any data point outside these whiskers is classified as an outlier. See Mcgill et al. (1978).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rptor^au93/au93 (AB)
Condition:	chemical treatment by environment: EC 3.4.22.56 (caspase-3) inhibitor
Observed In:	Meckel's cartilage
Stage:	Day 4

Phenotype Detail

Acknowledgments

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