FIGURE

Fig. 2

ID

ZDB-FIG-240425-16

Publication

Nieoczym et al., 2024 - A comprehensive assessment of palmatine as anticonvulsant agent - In vivo and in silico studies

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Fig. 2

PALM’s effect on the seizure-like behavior of gabra1-/- and scn1Lab-/- zebrafish mutants. Zebrafish larvae (4 or 5 dpf, respectively) were incubated for 2 or 24 h with PALM at a concentration of 450 µM. Results are displayed as maximum acceleration ± SEM [mm/s2]. Data were assessed via one-way ANOVA and Tukey’s post-hoc test. *p < 0.05, * **p < 0.001. 2 h treatment: gabra1+/+, n = 24;, gabra1-/-, n = 20; gabra1+/+ + PALM 450, n = 24; gabra1-/- + PALM 450, n = 20; 24 h treatment: gabra1+/+, n = 23; gabra1-/-, n = 17; gabra1+/+ + PALM 450, n = 24; gabra1-/- + PALM 450, n = 17; 2 h treatment: scn1Lab+/+, n = 96; scn1Lab-/-, n = 96; scn1Lab+/+ + PALM 450, n = 96; scn1Lab-/- + PALM 450, n = 96; 24 h treatment: scn1Lab+/+, n = 96; scn1Lab-/-, n = 97; scn1Lab+/+ + PALM 450, n = 97; scn1Lab-/- + PALM 450, n = 97. PALM – palmatine.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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