FIGURE

Fig. 6

ID

ZDB-FIG-240131-51

Publication

Li et al., 2024 - Cebp1 and Cebpβ transcriptional axis controls eosinophilopoiesis in zebrafish

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Fig. 6

Cebpβ promotes eosinophilopoiesis by regulating pre.Eos-related genes.

A Design of Cebpβ-target screening. RNA-Seq was performed with cebpb^+/+ and cebpb^−/− eosinophils to identify downregulated genes with cebpb mutation (470 genes, q < 0.05, baseMean > 50, log2 fold change > 0.7). ChIP-Seq was performed with Tg(hsp70:cebp1-eGFP) larvae to identify Cebpβ-binding genes (3381 genes, q < 0.05, peak fold enrich > 2, TSS ± 2 kb). B Downstream targets of Cebpβ. Seventy-five genes were found overlapped from the Cebpβ-binding genes and the downregulated genes with cebpb mutation. GO/KEGG analysis suggested that these genes are associated with ribosome (Red). The genes related to this GO term and eslec were exhibited by RNA-Seq heatmap. C Cebpβ binding on the proximal promoter of eslec. At the bottom panel, the direction of eslec transcription is marked with a black arrow, and the broad box and narrow box represent the coding sequence and UTR region, respectively. The red dotted box shows the binding peaks.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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