FIGURE

Figure 6

ID

ZDB-FIG-240113-35

Publication

Sobah et al., 2023 - Contribution of Signal Transducer and Activator of Transcription 3 (STAT3) to Bone Development and Repair

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Figure 6

Effect of Stat3 mutations on fin regeneration. Representative images of wildtype (WT: A), knockout (KO: B), and transactivation domain truncation (ΔTAD: C) zebrafish subjected to staining with calcein and Alizarin red at the indicated timepoints, showing staining with each separately and then overlaid (Merge), with scale bars representing 1 mm. Quantification of caudal fin regeneration as the length from the amputation site to the newly formed fin ray tip (D) showing mean with SEM and statistical significance indicated (*** p < 0.001). Relative survival following amputation (E), presented as a Kaplan–Meier plot with statistical significance indicated between WT and KO (*** p < 0.001) as well as WT and ΔTAD (### p < 0.001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	stat3^mdu35/mdu35 stat3^mdu36/mdu36
Condition:	amputation: caudal fin
Observed In:	caudal fin fin regeneration whole organism
Stage:	Days 14-20

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.