FIGURE

Fig. 2

ID

ZDB-FIG-231106-30

Publication

Doldur-Balli et al., 2023 - Pleiotropic effects of a high confidence Autism Spectrum Disorder gene, arid1b, on zebrafish sleep

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Fig. 2

arid1b−/− larvae are hyper-responsive to low stimulus intensities during the night. A. Stimulus-response curves for arid1b+/+, +/−, and −/− larvae from arousal threshold assay. B. arid1b−/− larvae show significantly increased (F_(2,27) = 10.10, p = 0.0005, by one-way ANOVA) responsiveness to lower intensity stimuli (<5 a.u.) compared to arid1b+/+ (p = 0.0031, by Tukey’s multiple comparisons test) and +/− (p = 0.0010, by Tukey’s multiple comparisons test). C. No significant differences were observed among groups at higher intensity stimuli (>5 a.u.). Asterisks indicate significance following p-value adjustment using Tukey’s multiple comparisons test. **p < 0.01, ***p < 0.001. Data are presented as mean ± 95% CI for group averages across each of 10 trials (n = 10 trials for 44 arid1b+/+, 94 arid1b +/−, and 45 arid1b −/− larvae).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	arid1b^y607/y607 arid1b^y607/+
Condition:	vibration
Observed In:	swimming behavior
Stage Range:	Day 5 to Days 7-13

Phenotype Detail

Acknowledgments

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