FIGURE

Fig. 2

ID

ZDB-FIG-230801-3

Publication

Wilson et al., 2022 - Tris(4-chlorophenyl)methane and tris(4-chlorophenyl)methanol disrupt pancreatic organogenesis and gene expression in zebrafish embryos

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Fig. 2

Exocrine pancreas area. Tg(ptf1a::GFP) zebrafish embryos were imaged and measured at 96 hpf following exposure to 50 nM tris(4-chlorophenyl)methanol (TCPMOH), 50 nM tris(4-chlorophenyl)methane (TCPM), or 0.01% DMSO. Asterisks (*) designate statistically significant changes from controls (p < .05). n = 26–32 embryos per exposure group. (a) Mean exocrine pancreas area of embryos exposed to 50 nM TCPMOH and 50 nM TCPM were reduced by 13% and 8.8%, respectively, compared to controls. (b) Incidence of hypomorphic pancreases was significantly increased in TCPMOH-exposed embryos, accounting for one-third of those exposed.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	jh1Tg/jh1Tg
Conditions:	chemical treatment by environment: TCPM chemical treatment by environment: TCPMOH
Observed In:	pancreas
Stage:	Day 4

Phenotype Detail

Acknowledgments

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