Fig. 3
- ID
- ZDB-FIG-230713-19
- Publication
- Ma et al., 2023 - Oxoeicosanoid signaling mediates early antimicrobial defense in zebrafish
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Oxoeicosanoid and not LTB4 signaling regulates early neutrophil recruitment along with microbial pattern recognition
(A and B) Myd88 and pycard mutations (F0 CRISPR) inhibit early neutrophil recruitment to infected ears to a similar extent as hcar1–4mk214 −/− mutation does but without having an additive effect to the latter. (C and D) Unlike the hcar1–4mk214 −/− mutation, lta4h and ltb4r F0 CRISPR mutations do not inhibit early neutrophil recruitment to infected ears. Violin plot points denote counts of Sudan-black-stained neutrophils in individual larvae. Violin plots lines denote first quartiles (top line), medians (middle line), and third quartiles (bottom line). **p < 0.01; ***p < 0.001; ****p < 0.0001; n.s., p > 0.05; Student’s t test (two tailed, two sample unequal variance test). Parentheses, total number of injected larvae. See also Figure S4. |