FIGURE

Figure 5

ID

ZDB-FIG-230609-14

Publication

Grabinski et al., 2023 - Comparative analysis of transcriptional changes in zebrafish cep290 and bbs2 mutants by RNA-seq reveals upregulation of inflammatory and stress-related pathways

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Figure 5

Fold change of gene expression in cep290 and bbs2 mutant retinas compared to wild-type animals. qRT-PCR of selected genes involved in inflammatory signaling and apoptosis processes in 6 mpf mutants. Gene expression was normalized to 18S reference gene expression and plotted relative to expression in wild-type siblings. Data are plotted as the mean ± S.D. Three technical replicates were conducted on each of four distinct biological samples of RNA. At least 2 retinas were pooled for each biological sample. *p < 0.05 by way of two-way Mann Whitney tests.

Expression Data

Genes:	atf3 atf5a cd44a fosab il11a irf1b irf9 jun junbb mych myclb stat1a
Fish:	WT bbs2^lri82/lri82 cep290^fh297/fh297
Anatomical Term:	retina
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bbs2^lri82/lri82 cep290^fh297/fh297
Observed In:	retina
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.