Gene
cd44a
- ID
- ZDB-GENE-110429-1
- Name
- CD44 molecule (IN blood group) a
- Symbol
- cd44a Nomenclature History
- Previous Names
-
- cd44
- fa99e04
- wu:fa99e04
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable hyaluronic acid binding activity and transmembrane signaling receptor activity. Predicted to contribute to cytokine receptor activity. Acts upstream of or within vasculature development. Predicted to be located in membrane and microvillus. Predicted to be part of macrophage migration inhibitory factor receptor complex. Predicted to be active in basolateral plasma membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb231 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| ihb232 | Allele with one insertion | Exon 2 | Unknown | CRISPR | |
| sa21059 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34175 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zf3632 | Allele with one delins | Exon 2 | Unknown | CRISPR | |
| zf3633 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [Blood group, Indian system] | 609027 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CD44 antigen | CD44 antigen-like | C-type lectin fold | C-type lectin-like/link domain superfamily | Link domain |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A7T1AGS9
|
||||||
|
UniProtKB:E7F6T0
|
392 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-102L7 | ||
| Encodes | EST | fa99e04 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001922456 (1) | 1750 nt | ||
| Genomic | GenBank:CR318591 (2) | 109921 nt | ||
| Polypeptide | UniProtKB:E7F6T0 (1) | 392 aa |
- Grabinski, S.E., Parsana, D., Perkins, B.D. (2023) Comparative analysis of transcriptional changes in zebrafish cep290 and bbs2 mutants by RNA-seq reveals upregulation of inflammatory and stress-related pathways. Frontiers in molecular neuroscience. 16:11488401148840
- Cao, L., Fang, H., Yan, D., Wu, X.M., Zhang, J., Chang, M.X. (2022) CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Communications biology. 5:889
- Mu, X., Qi, S., Wang, H., Yuan, L., Wang, C., Li, Y., Qiu, J. (2022) Bisphenol analogues induced metabolic effects through eliciting intestinal cell heterogeneous response. Environment International. 165:107287
- Newman, M., Nik, H.M., Sutherland, G.T., Hin, N., Kim, W.S., Halliday, G.M., Jayadev, S., Smith, C., Laird, A., Lucas, C., Kittipassorn, T., Peet, D.J., Lardelli, M. (2020) Accelerated loss of hypoxia response in zebrafish with familial Alzheimer's disease-like mutation of Presenilin 1. Human molecular genetics. 29(14):2379-2394
- Cao, L., Wu, X.M., Nie, P., Chang, M.X. (2019) The negative regulation of piscine CD44c in viral and bacterial infection. Developmental and comparative immunology. 96:135-143
- Wu, X.M., Chen, W.Q., Hu, Y.W., Cao, L., Nie, P., Chang, M.X. (2018) RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways. Frontiers in immunology. 9:726
- Hu, Y.W., Wu, X.M., Ren, S.S., Cao, L., Nie, P., Chang, M.X. (2017) NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway. Scientific Reports. 7:2979
- Moore, F.E., Garcia, E.G., Lobbardi, R., Jain, E., Tang, Q., Moore, J.C., Cortes, M., Molodtsov, A., Kasheta, M., Luo, C.C., Garcia, A.J., Mylvaganam, R., Yoder, J.A., Blackburn, J.S., Sadreyev, R.I., Ceol, C.J., North, T.E., Langenau, D.M. (2016) Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish. The Journal of experimental medicine. 213(6):979-92
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Yakkundi, A., Bennett, R., Hernández-Negrete, I., Delalande, J.M., Hanna, M., Lyubomska, O., Arthur, K., Short, A., McKeen, H., Nelson, L., McCrudden, C.M., McNally, R., McClements, L., McCarthy, H.O., Burns, A.J., Bicknell, R., Kissenpfennig, A., Robson, T. (2015) FKBPL Is a Critical Antiangiogenic Regulator of Developmental and Pathological Angiogenesis. Arterioscler. Thromb. Vasc. Biol.. 35(4):845-54
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