FIGURE

Fig. 2

ID

ZDB-FIG-230605-7

Publication

Casey et al., 2022 - The scaffolding function of LSD1/KDM1A reinforces a negative feedback loop to repress stem cell gene expression during primitive hematopoiesis

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Expression of GFI-family transcription factors are dysregulated in lsd1 mutants

(A–F) Whole-mount in situ hybridization (WISH) of embryos derived from an incross of either kdm1a(23095) heterozygotes (A–C) or kdm1a(36433) heterozygotes (D–F) using probes to detect gfi1aa (A and D), gfi1ab (B and E), or gfi1b (C and F), as indicated. Representative images are shown with the number of animals with similar staining patterns for the indicated genotype shown in the upper right corner of each image. The lower left corner indicates the approximate stage of the animal at the time of fixation. Embryos were imaged, blindly scored by expression levels and then genotyped by HRMA. Carons indicate ICM expression; closed arrowheads indicate posterior blood island/caudal hematopoietic tissue; narrow triangles indicate inner-hair-cell expression. Scale bar, 200 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ iScience