FIGURE

Fig. 4.

ID

ZDB-FIG-230518-105

Publication

Keatinge et al., 2023 - Unexpected phenotypic and molecular changes of combined glucocerebrosidase and acid sphingomyelinase deficiency

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Fig. 4.

Gaucher cell accumulation in the retina of gba1^−/−;smpd1^−/− double mutants. (A) Analysis of the numbers of 4C4-positive cells within the retina revealed comparatively significant increases of ∼50% in both gba1^−/− (P=0.0026) and gba1^−/−;smpd1^−/− mutants (P=0.0193) compared to those in WT, despite enhancement of key glycolipid levels in the double mutants. 4C4-positive cell counts in smpd1^−/− were not statistically different to those in WT. Data represented are the mean±s.d. *P<0.05; **P<0.01 (two-way ANOVA). n= 4 for all groups. (B) 4C4-positive cells in the retina of the gba1^−/− and gba1^−/−;smpd1^−/− double mutants were localised throughout the retina and appeared larger and rounder (arrows) compared to ramified WT 4C4-positive cells (arrowheads). Scale bar: 50 μm.

Expression Data

Antibody:	Ab-4C4
Fish:	WT gba1^sh391/sh391 smpd1^sh696/sh696 gba1^sh391/sh391; smpd1^sh696/sh696
Anatomical Term:	retina microglial cell
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gba1^sh391/sh391 smpd1^sh696/sh696 gba1^sh391/sh391; smpd1^sh696/sh696
Observed In:	retina microglial cell
Stage:	Adult

Phenotype Detail

Acknowledgments

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