FIGURE
Figure 5
- ID
- ZDB-FIG-230401-7
- Publication
- Pezzotta et al., 2023 - Combined Inhibition of Hedgehog and HDAC6: In Vitro and In Vivo Studies Reveal a New Role for Lysosomal Stress in Reducing Glioblastoma Cell Viability
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Figure 5
LC3 and LAMP1 colocalization and BODIPY-SM distribution were impaired following Hh and HDAC6 inhibition. (A) Double immunostaining against LC3 and LAMP1 of U87-MG cells treated in the presence or absence of both 8 μM of TubA and 10 μM of cyclo. Asterisks show some LC3 puncta, indicating autophagosomes, that did not colocalize with the red ones, indicating lysosomes. (B) BODIPY-SM and LysoTracker Red DND-99 staining of U87-MG cells treated in the presence or absence of both 8 μM of TubA and 10 μM of cyclo. CT—control, TubA/T—tubastatin A; cyclo/C—cyclopamine. Scale bar indicates 40 μm. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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