FIGURE

Figure 2

ID

ZDB-FIG-230228-119

Publication

Ritter et al., 2023 - Rgp1 contributes to craniofacial cartilage development and Rab8a-mediated collagen II secretion

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Figure 2

Rab6a vesicle trafficking is reduced in rgp1^-/- chondrocytes (A) Experimental design for mosaic overexpression of WT mCherry-zRab6a fusion protein in Tg(Col2a1α:caax-eGFP) transgenic zebrafish chondrocytes for live imaging. (B) Representative images from movies of mCherry-zRab6a vesicular compartment movement in chondrocytes ( Supplemental Movies 1, 2). (C) Montage of mCherry-zRab6a puncta progression at specific times in WT and rgp1^-/- chondrocytes (yellow arrowheads) showing path of indicated vesicle over time (white line). (D) Quantification of vesicular compartment distances traveled in WT and rgp1^-/- chondrocytes. Red lines indicate means. (E) Quantification of vesicular compartment speeds in WT and rgp1^-/- chondrocytes. Red lines indicate means. Significance is presented by ****p<0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)