FIGURE

Figure 5

ID

ZDB-FIG-230221-13

Publication

van der Plas et al., 2023 - Neural assemblies uncovered by generative modeling explain whole-brain activity statistics and reflect structural connectivity

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Figure 5

cRBM gives rise to functional connectivity that is strongly correlated across individuals.

(A) The functional connectivity matrix between anatomical regions of the mapzebrain atlas (Kunst et al., 2019) of example fish #2 is shown. Functional connections between two anatomical regions were determined by the similarity of the HUs to which neurons from both regions connect to (Materials and methods). Mapzebrain atlas regions with less than five imaged neurons were excluded, yielding $N_{MAP} = 50$ $N_{MAP} = 50$ regions in total. See Supplementary file 1 for region name abbreviations. The matrix is shown in log₁₀ scale, because functional connections are distributed approximately log-normal (see panel D). (B) Equivalent figure for example fish #3 (example fish of prior figures). (C) Equivalent figure for example fish #4. Panels A-C share the same log₁₀ color scale (right). (D) Functional connections are distributed approximately log-normal. (Mutual information with a log-normal fit (black dashed line) is 3.83, while the mutual information with a normal fit is 0.13). All connections of all eight fish are shown, in log₁₀ scale (purple). (E) Functional connections of different fish correlate well, exemplified by the three example fish of panels A-C. All non-zero functional connections (x-axis and y-axis) are shown, in log₁₀ scale. Pearson correlation $r_{P}$ $r_{P}$ between pairs: $r_{P} (# 2, # 3) = 0.73$ $r_{P} (# 2, # 3) = 0.73$ , $r_{P} (# 2, # 4) = 0.73$ $r_{P} (# 2, # 4) = 0.73$ , $r_{P} (# 3, # 4) = 0.78$ $r_{P} (# 3, # 4) = 0.78$ . All correlation p values $< 10^{- 20}$ $< 10^{- 20}$ (two-sided t-test). (F) Pearson correlations $r_{P}$ $r_{P}$ of region-to-region functional connections between all pairs of 8 fish. For each pair, regions with less than five neurons in either fish were excluded. All p values $< 10^{- 20}$ $< 10^{- 20}$ (two-sided t-test), and average correlation value is 0.69.

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Acknowledgments

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