FIGURE

Fig. 1

ID

ZDB-FIG-220920-69

Publication

Tian et al., 2022 - WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome

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Fig. 1

The wrn mutant zebrafish exhibit shortened body length.

a Representative bright-field images of 3 independent experiments between WT and wrn^−/− mutant zebrafish at 40 hpf. Scale bar = 100 µm. b Dot graph analysis of the total body length of WT and wrn^−/− mutants from 4 dpf to 14 dpf. N = 25 independent embryos for WT and wrn^−/− mutants, respectively. Each dot represents a biological replicate. c–f Representative calcein green staining of 3 independent experiments to examine bone formation between WT and wrn^−/− mutant zebrafish from 3 dpf to 14 dpf. White arrows indicate vertebrate regions. Scale bar = 100 µm. Data are presented as the mean ± S.D. Statistical analysis was performed using two-tailed unpaired Student’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	wrn^{sa34829/sa34829}
Observed In:	bone growth whole organism
Stage Range:	Protruding-mouth to Days 14-20

Phenotype Detail

Acknowledgments

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