Fig. 2
- ID
- ZDB-FIG-220908-24
- Publication
- Ma et al., 2022 - Ercc2/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress
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Digestive organ development is defective in ercc2/xpd mutants (A) Transcriptomic analysis revealed reduced expression of genes related to digestion and metabolism in ercc2/xpd mutants compared to siblings at 5 and 7 dpf. (B) Whole-mount in situ hybridization showing reduced expression of marker genes of intestine, liver, and exocrine, but not endocrine, pancreas, in ercc2/xpd mutants compared to siblings at 5 and 7 dpf. Lateral view, anterior to the left. Scale bar, 100 μm. See also Figure S3. (C) HE staining of sagittal and transverse sections of ercc2/xpd mutants and siblings at 5 and 7 dpf. The intestinal cavity in mutants is smaller or collapsed. Red arrowheads indicate detached cells and cellular debris. Scale bars, 25 μm. See also Figure S4A. (D) HE staining showing vacuolar liver (asterisks) and lipid droplets (arrowheads) in ercc2/xpd mutant liver sections at 7 dpf. Scale bars, 25 μm. (E) Whole-mount Oil Red O (ORO) staining showing fatty liver (dashed area) in ercc2/xpd mutants at 7 dpf. Lateral view, anterior to the left. Scale bar, 200 μm. See also Figure S4. |
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| Stage Range: | Day 4 to Days 7-13 |
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| Stage Range: | Day 5 to Days 7-13 |