FIGURE

Fig 4

ID

ZDB-FIG-220904-25

Publication

Wang et al., 2022 - Reduced sister chromatid cohesion acts as a tumor penetrance modifier

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Fig 4

Elevated mitotic segregation errors in esco2 haploinsufficient embryos.

(A) in-vivo confocal imaging of H2A.F/Z-EGFP and CaaX-mCherry mRNA injected embryos at 24 hours post-fertilization (hpf) for two hours. Representative images of normal and defective mitoses in esco2^+/+ and esco2^m/+. Arrow in anaphase bridge time-lapse points towards the anaphase bridge formed. Dotted circular in tri-polar time-lapse represents the three future nuclei that will occur. CaaX-mCherry was removed in tri-polar time-lapse for better visualization. t = time in minutes. (B) Division time calculated for each division in six esco2^+/+ and ten esco2^m/+embryos using two-hour imaging time-lapse data from each embryo. The percentage of cells was calculated for each bin category. N = 73 for esco2^+/+ and N = 132 for esco2^m/+. (C) Table representing mitotic defects and the associated mitotic timing and cell fate observed in six esco2^+/+ and ten esco2^m/+embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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