FIGURE

Figure 4

ID

ZDB-FIG-220827-17

Publication

Crouzier et al., 2022 - Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines

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Figure 4

Analysis of the quantity of movement of 5 dpf wfs1 mutant larvae during the noise cycle in the ASR test. (A) Sound protocol: the activity is measured for 45 min in a total dark (OFF) condition, with a training phase for 30 min silently, then three cycles of white sounds (90 dB) of 1 s each and 5 min interspersed. Quantity of movement per second for (B) the wfs1a^C825X and (F) wfs1b^W493X larvae according to the sound protocol. Relative quantity of movement during (C, G) the training phase [blue-dotted lines in (B, F) between 21 and 29 min]; (D, H) the baseline phase, period of 2 min before each sound (the averaged three baseline phases); (E, I) the three stimulations (the averaged sounds phases). Activity was expressed as % of associated controls. Error bars represent ± SEM calculated from three replicas. The number of animals is indicated below the columns. ^*P < 0.05; unpaired t-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	wfs1a^{sa11465/sa11465} (AB) wfs1b^{sa16422/sa16422} (AB)
Observed In:	response to auditory stimulus
Stage:	Day 5

Phenotype Detail

Acknowledgments

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