FIGURE

Fig. 4

ID

ZDB-FIG-220810-57

Publication

Fu et al., 2022 - N-methyl-N-nitrosourea induces zebrafish anomalous angiogenesis through Wnt/β-catenin pathway

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Fig. 4

Fig. 4. Rspo1 is required for MNU-induced abnormal angiogenesis. A. Representative images of ISV and hindbrain vessels from control group, MNU-treated group, rspo1 MO-treated group and MNU-treated rspo1 MO group at 48 hpf. White arrows point to ectopic ISV branches. To better observe the phenotype, the concentration of rspo1 MO used was 150 μM for imaging analysis. Red arrows indicate the central artery (CA). Scale bar, 50 µm. B. Quantitative analysis of ectopic intersegmental vessel (ISV) branches in control group, MNU-treated group, rspo1 MO-injected group and rspo1 MO plus MNU-treated group at 48 hpf. Data were obtained from three independent experiments and are expressed as the mean ± SEM. * ** * P < 0.0001, * * P < 0.01, * P < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s843Tg/s843Tg s843Tg/s843Tg + MO3-rspo1
Condition:	chemical treatment by environment: N-methyl-N-nitrosourea
Knockdown Reagent:	MO3-rspo1
Observed In:	intersegmental vessel branching involved in blood vessel morphogenesis mid cerebral vein branching involved in blood vessel morphogenesis
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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