FIGURE

Fig. 1

ID

ZDB-FIG-220715-49

Publication

Berger et al., 2022 - Mob4-dependent STRIPAK involves the chaperonin TRiC to coordinate myofibril and microtubule network growth

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Fig. 1

The muscle integrity is compromised in gemütlich (geh) mutants.

(A) At 3 dpf, geh mutants appeared unremarkable under bright-field microscopy. (B) In comparison to their siblings, (B’) 3-dpf-old geh homozygotes appeared darker in representative images taken under polarised light conditions. (C) After rescaling to siblings (100 ± 1%), the birefringence of 3-dpf-old geh homozygotes was significantly reduced to 61 ± 1%. Crosses represent averaged birefringence of clutches with a minimum of 6 larvae per genotype (n = 5 clutches). Data are presented as mean ± SEM; *** P < 0.001 calculated by Student’s t-test. (D) Fibrotic signs were not detected on H&E-stained cross sections of 3-dpf-old geh homozygotes and siblings (n = 6 per genotype). Scale bar sizes are indicated.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mob4^pc43/pc43 (TU)
Observed In:	myotome myotome skeletal muscle myofibril
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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