FIGURE

Fig. 4

ID

ZDB-FIG-220715-29

Publication

Santistevan et al., 2022 - cacna2d3, a voltage-gated calcium channel subunit, functions in vertebrate habituation learning and the startle sensitivity threshold

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Fig. 4

Fig 4. cacna2d3 mutants and trans-heterozygotes exhibit decreased startle latency.

Startle kinematic analysis of C-turn latency and C-turn duration. (A) Latency and (B) duration analysis and of wild-type (shown in blue) and cacna2d3^p177 mutants (shown in red). (A-B) ns, ****p<0.0001, Mann-Whitney test versus wild-type. (C) Latency and (D) duration analysis of cacna2d3^sa16189 wild-type (shown in blue), heterozygous (shown in black) and mutant larvae (shown in red). (E) Latency and (F) duration analysis of cacna2d3^sa16051 wild-type (shown in blue), heterozygous (shown in black) and mutant larvae (shown in red). (C, E) ***p<0.001, ****p<0.0001, one-way ANOVA with Dunnett’s multiple comparison test versus wild-type.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cacna2d3^p177/p177 (TL) cacna2d3^{sa16051/sa16051} cacna2d3^{sa16189/sa16189} cacna2d3^p177/+ (TL) cacna2d3^sa16051/+ cacna2d3^sa16189/+ cacna2d3^p177/+; cacna2d3^sa16051/+ cacna2d3^p177/+; cacna2d3^sa16189/+
Observed In:	startle response
Stage:	Day 5

Phenotype Detail

Acknowledgments

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