FIGURE

Figure 5

ID

ZDB-FIG-220520-6

Publication

Duclaux-Loras et al., 2022 - UNC45A deficiency causes microvillus inclusion disease-like phenotype by impairing myosin VB-dependent apical trafficking

Other Figures

All Figure Page

Back to All Figure Page

Figure 5

UNC45A-deficient organoids recapitulate MVID features.

(A) Bright-field images of control, P1, P4, and UNC45A^KO1 3D organoids. Scale bar: 5000 μm. (B) F-actin staining revealing MVIs in the small subset of P1, P4, and UNC45A^KO 3D organoids that display a central lumen. Scale bar: 20 μm. (C) STED image of F-actin at the apical pole of 2D enterocyte cultures derived from control, P1, P4, and UNC45A^KO1 organoids after a 21-day culture on filters. Scale bars: 1 μm. L, lumen.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Journal of Clin. Invest.