FIGURE

Figure 4

ID

ZDB-FIG-220515-4

Publication

Xu et al., 2022 - Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish

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Figure 4

Nur77 regulates lipid metabolism in zebrafish larvae. (A) Heatmaps of transcripts in lipid metabolism enrichment. Colors represent high (red), low (blue), or average (white) expression values based on Z-score-normalized fragments per kilobase per million mapped read (FPKM) values for each gene. The Z-score indicators are shown under each map. The fold change (log2) is shown on the right. (B) The validation of the expression levels of differentially expressed genes by qRT-PCR analysis in the categories of lipid metabolism (n = 3). (C) Disturbed cholesterol biosynthesis. Blocks represent transcript-encoded enzymes. Green blocks represent downregulated genes, and black blocks represent unchanged genes. (D) The whole-body cholesterol (TC) contents of WT and nur77^−/− zebrafish (n = 3). (E) The whole-body total triglyceride (TG) contents of WT and nur77^−/− zebrafish. Results are represented as means with standard errors (n = 3); ^*p < 0.05, ^***p < 0.001, ^****p < 0.0001 by t-test.

Expression Data

Genes:	cyp2p9 cyp51 hadhaa hmgcs1 lss sc5d sqlea ugt5a1 ugt5a5
Fish:	nr4a1^{xmu201/xmu201} (AB)
Anatomical Term:	whole organism
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nr4a1^{xmu201/xmu201} (AB)
Observed In:	whole organism whole organism cholesterol whole organism triglyceride
Stage:	Day 6

Phenotype Detail

Acknowledgments

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