Gene
hadhaa
- ID
- ZDB-GENE-031222-5
- Name
- hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a
- Symbol
- hadhaa Nomenclature History
- Previous Names
-
- hadha
- cb1055 (1)
- im:7136067
- wu:fa14c08
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have enoyl-CoA hydratase activity and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Involved in response to bacterium. Predicted to localize to mitochondrial fatty acid beta-oxidation multienzyme complex. Human ortholog(s) of this gene implicated in fatty liver disease and mitochondrial trifunctional protein deficiency. Is expressed in several structures, including cardiovascular system; midbrain; midbrain neural tube; musculature system; and pleuroperitoneal region. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 18 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1055 (13 images)
- IMAGE:7136067 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR006180 | 3-hydroxyacyl-CoA dehydrogenase, conserved site |
Conserved_site | IPR018376 | Enoyl-CoA hydratase/isomerase, conserved site |
Domain | IPR006108 | 3-hydroxyacyl-CoA dehydrogenase, C-terminal |
Domain | IPR006176 | 3-hydroxyacyl-CoA dehydrogenase, NAD binding |
Family | IPR001753 | Enoyl-CoA hydratase/isomerase |
Family | IPR012803 | Fatty acid oxidation complex, alpha subunit, mitochondrial |
Family | IPR050136 | Fatty acid oxidation complex subunit alpha |
Homologous_superfamily | IPR008927 | 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily |
Homologous_superfamily | IPR029045 | ClpP/crotonase-like domain superfamily |
Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
Protein | Length | 3-hydroxyacyl-CoA dehydrogenase, conserved site | 3-hydroxyacyl-CoA dehydrogenase, C-terminal | 3-hydroxyacyl-CoA dehydrogenase, NAD binding | 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily | ClpP/crotonase-like domain superfamily | Enoyl-CoA hydratase/isomerase | Enoyl-CoA hydratase/isomerase, conserved site | Fatty acid oxidation complex, alpha subunit, mitochondrial | Fatty acid oxidation complex subunit alpha | NAD(P)-binding domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A7YT47
|
761 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
hadhaa-201
(1)
|
Ensembl | 2,782 nt |
Interactions and Pathways
No data available
Plasmids
No data available