FIGURE

FIGURE 8

ID

ZDB-FIG-220227-9

Publication

Leggieri et al., 2022 - Ankk1 Loss of Function Disrupts Dopaminergic Pathways in Zebrafish

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FIGURE 8

Habituation to acoustic startle response in 5 days post fertilization larvae (ankk1^+/+, ankk1^+/27ins, and ankk1^27ins/27ins) in presence (0.01 mg/L) or absence (control) of amisulpride. The assay consisted of 60 s of basal tracking, followed by 20 acoustic stimuli within 2 s intervals. (A,C,E) Mean distances traveled by ankk1^+/+, ankk1^+/27ins, ankk1^27ins/27ins. Sample size: N = 145 per genotype. (B,D,F) Proportion of individuals responding to each startle stimulus. N = 226 ankk1^+/+_control, N = ankk1^+/27ins_control, N = 226 ankk1^27ins/27ins _control, N = 226 ankk1^+/+_AMI, N = 145 ankk1^+/27ins _AMI, N = 145 ankk1^27ins/27ins _AMI, N = 145 ankk1^+/+_APO, N = 145 ankk1^+/27ins _APO, N = 145 ankk1^27ins/27ins _APO. Error bars show standard error of the mean.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TU ankk1^qm3/qm3 (TU) ankk1^qm3/+ (TU)
Conditions:	chemical treatment by environment: amisulpride chemical treatment by environment: apomorphine
Observed In:	habituation startle response
Stage:	Day 5

Phenotype Detail

Acknowledgments

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