FIGURE

Figure 6

ID

ZDB-FIG-220131-125

Publication

Bu et al., 2021 - Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish

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Figure 6

Therapeutic effects of mtor inhibition on the VAC model.

(A and B) Representative Western blots showing the levels of proteins involved in mTOR signaling pathways in WT controls, vmhcl^e13/+, and vmhcl^e13/+mtor^xu015/+ mutants and quantification analysis. n = 3 biological replicates; data are presented as the mean ± SD; 1-way ANOVA. (C and D) Quantification of the percent EF and FS using echocardiography in fish at 8 months. n = 12; data are presented as the mean ± SD; 1-way ANOVA. (E and F) Representative images of isolated hearts and H&E staining in the apex area in fish at 8 months. (G and H) Quantification of the VSA normalized to BW and trabecular muscle density in these mutants and WT controls at 8 months. n = 6; data are presented as the mean ± SD; 1-way ANOVA. Scale bars: 2 mm in E and 300 μm in F.

Expression Data

Antibodies:	Ab1-rps6 Ab7-mtor Ab11-map1lc3
Fish:	myh7l^xu093/+ myh7l^xu093/+; mtor^xu015Gt/+
Anatomical Term:	heart
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mtor^xu015Gt/+ myh7l^xu093/+ myh7l^xu093/+; mtor^xu015Gt/+
Observed In:	cardiac ventricle heart heart contraction myocardium
Stage:	Adult

Phenotype Detail

Acknowledgments

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