FIGURE

Fig. 2

ID

ZDB-FIG-220112-11

Publication

Mullapudi et al., 2019 - Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function

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Fig. 2

dnVegfaa exerts a dose-dependent effect on β-cell dispersion. (A) β-Cells (green) from 48 hpf Tg(ins:GFP) embryos with mosaic Tg(ins:dnvegfaa) expression. The percentage of β-cells expressing dnvegfaa (magenta) is indicated, as is the severity of islet dispersion (intact, moderate or severe; white). (B) Quantification of embryos displaying varying severity of islet dispersion. (C-J) Immunostaining for insulin (β-cells, red) and endothelial cells (green) in 48 hpf Tg(fli:GFP) embryos, in combination with the indicated transgenic or mutant line, n=3-5 animals per genotype. Maximum intensity projections are presented. A, anterior; D, dorsal.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bns282Tg; zf5Tg bns284Tg; y1Tg bns286Tg; y1Tg flt1^bns29/bns29; y1Tg kdr^bns32/bns32; y1Tg kdrl^{hu5088/hu5088}; y1Tg vegfaa^bns1/bns1; y1Tg vegfab^bns92/bns92; y1Tg
Observed In:	blood vasculature endocrine pancreas endocrine pancreas blood vasculature primary islet
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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