FIGURE

Fig 7

ID

ZDB-FIG-211122-29

Publication

Kikel-Coury et al., 2021 - Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function

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Fig 7

Meteorin acts as a molecular determinant of CNG.

(A) Schematic representation of metrn CRISPR mutation (red). (B) Confocal z-sections of metrn, id1, and cdh11 mRNA in the ventricle (white dotted outline) at 6 dpf in wild-type and metrn^−/− embryos. (C) Quantification of percent survival of adult wild-type and metrn^+/− animals. (D) Confocal maximum z-projection of nucGFP⁺ number (white arrowheads) in the ventricle (white dotted outline) at 6 dpf in Tg(gfap:nucGFP) wild-type and metrn^−/− embryos. (E) Quantification of Tg(gfap:nucGFP)⁺ number at 6 dpf over various manipulations of the differentiation pathway. (F) Quantification of Tg(gfap:nucGFP)⁺ number after wash-in/wash-out of S31-201 at different time points. Crossover between the curves indicates a functional role between 4–5 dpf. Data are represented as mean ± SEM. Scale bar equals 10 μm. Statistics summarized in S1 Table. See S1 Data for raw data. aa, amino acid; CNG, cardiac nexus glia; dpf, days postfertilization; mpf, months postfertilization; V, ventricle.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mi2004Tg metrn^nt200/nt200; mi2004Tg
Conditions:	chemical treatment by environment: 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one chemical treatment by environment: S3I-201
Observed In:	heart heart cardiac glial cell differentiation heart glial cell (sensu Vertebrata) heart neural crest-derived cardiac glial cell differentiation
Stage:	Day 6

Phenotype Detail

Acknowledgments

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