FIGURE

Figure 4

ID

ZDB-FIG-211120-44

Publication

Ding et al., 2021 - The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling

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Figure 4

Transcriptional disruption of genes related to erythrocyte function and homeostasis after smarca5 deletion.

(A) Schematic representation of the RBC RNA-seq workflow in smarca5^zko1049a and their siblings at 2 dpf. (B) Volcano plot showing differential expression genes between RBCs from smarca5^zko1049a and their siblings by DESeq2. −Log10 P, negative log10 adjusted p-value. Adjusted p-value < 0.05, log2 fold change >1. (C) Differential pathways enriched in RBCs from smarca5^zko1049a and their siblings by GSVA. The x axis represents the t values of GSVA scores. Two-sided unpaired limma-moderated t test. (D) Enrichment plots for the top pathways in the mutant RBCs by GSEA (Gene Set Enrichment Analysis).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	smarca5^{zko1049a/zko1049a}; sd2Tg/sd2Tg
Observed In:	nucleate erythrocyte apoptotic process nucleate erythrocyte cellular response to oxidative stress nucleate erythrocyte cellular senescence nucleate erythrocyte inflammatory response
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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